MORC3 and calcinosis: Anti-TIF1 is associated with skin ulceration, photosensitive skin rashes, lipodystrophy, and edema (24, 75–78), whereas anti-NXP2 is associated with a severe disease course with more profound muscle involvement, calcinosis, gastrointestinal ulceration, joint contractures, and dysphonia (75, 77, 79, 80).