Nevertheless, the relative decline in disease severity observed with age (e.g., decreased B cell lymphocytosis, splenomegaly, and atopic symptoms) suggests the strongest phenotypic effects stemming from abnormal CARD11 signaling are ultimately overcome or somehow circumvented over time, as noted in both classic BENTA and CARD11 DN atopic patients. This evidence concerns the gene CARD11 and Splenomegaly.