Some of these mAbs, especially those directed to PD-1 (Nivolumab and Pembrolizumab) expressed on activated CTLs, or PDL-1 (Atezolizumab, Durvalumab, and Avelumab) expressed on inflammatory and cancer cells, have in fact, gained a stable role in the treatment of very common malignancies such as non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and urological malignancies, where they are capable of producing significant benefit to many patients and prolonging their survival in about a quarter of the cases (4). Here, CD274 is linked to head and neck squamous cell carcinoma.