To further assess the suggested importance of IL-4Rα expression on B cells for the down-regulation of S. mansoni egg-driven fibrogranulomatous inflammation, we performed a low dose infection of mb1creIL-4Rα−/lox mice (30 live S. mansoni cercariae) and killed mice at 16 (chronic) and 24 (advanced chronic) weeks post-infection to analyse tissue pathology and immune profiles of chronically infected mice. This evidence concerns the gene IL4R and infection.