Analysis of the cytokine profile produced by total MLN cells restimulated with 20 μg/ml of α-CD3 revealed that the production of IL-10 was significantly decreased in mb1creIL-4Rα−/lox mice compared to littermate control mice while the concentrations of IL-4, IL-5, and IFN-γ were similar in all mutants at 16 weeks post-infection (Figure 2C). The gene discussed is IFNG; the disease is infection.