It has been shown in many different tumors that secretion of various cytokines (including IL-6, IL-10, IL-35, and TGF-β) from Bregs support the activation and expansion of Tregs, TAMs, and MDSCs around the tumor bed, thereby skewing these cells toward suppressive subsets to enhance the tumor-promoting microenvironment (134, 135). The gene discussed is IL10; the disease is neoplasm.