Inspired by iPSCs technology and the similarity between iPSCs and cancer stem cells reprogramming, researchers generated glioma stem-like state cells through a dedifferentiated process of glioma cells by overexpression of crucial genes: POU3F2, SOX2, OLIG2, and SALL2 (18), which indicates the impact of critical tumor-promoting genes on the fate of GSCs and further regulation of glioma development. This evidence concerns the gene SOX2 and glioma.