HSV-1 seropositive individuals were divided into two groups: (i) ten HLA-A*02:01 positive, HSV-1-infected ASYMP individuals who have never had any clinically detectable herpes disease; and (ii) ten HLA-A*02:01 positive HSV-1-infected SYMP individuals with a history of numerous episodes of well-documented recurrent clinical herpes diseases, such as herpetic lid lesions, herpetic conjunctivitis, dendritic or geographic keratitis, stromal keratitis, and iritis consistent with rHSK, with one or more episodes per year for the past 5 years. This evidence concerns the gene HLA-A and iritis.