Nevertheless, we found that regulation of CD8+ T cell exhaustion by LAG-3 and PD-1 inhibitory pathways was non-redundant, as blockade of the T cell inhibitory receptors LAG-3 and PD-1 simultaneously and synergistically improved CD8+ T cell responses and diminished HSV-1 load and recurrent disease in HLA Tg mice (Roy et al., under review). This evidence concerns the gene CD8A and disease recurrence.