Despite mounting evidence about its pro-carcinogenic activities, NLRP3 deficiency has been linked not only to an increased number of colon polyps but also to a greater susceptibility to colon cancer development in an AOM-DSS mouse model, suggesting a protective role for NLRP3 in colon carcinogenesis (133). The gene discussed is NLRP3; the disease is malignant colon neoplasm.