NLRP3 and malignant colon neoplasm: Relevant studies focused on the activity of the inflammasome in cancer development have demonstrated that NLRP3 is highly expressed in a cell line of mesenchymal-like colon cancer cells with its expression being upregulated by TNF-α and transforming growth factor-β1 (TGF-β1) during the epithelial-mesenchymal transition (143).