IL-2 immunocytokines-targeted proteins are represented by either surface membrane TAAs, such as disialoganglioside 2 (GD2), epithelial cell adhesion molecule (EpCAM), carcinoembryonic antigen (CEA), CD20, and CD30 or proteins belonging to tumor extracellular matrix (ECM) like extra domain A (ED-A) and B (ED-B) of Fibronectin A-FN and B-FN, respectively and tenascin-C. This evidence concerns the gene IL2 and neoplasm.