NLRP3 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: Recently, Chae et al. (20) found that PBMCs of APLAID patients secreted IL-1β after LPS stimulation, while PBMCs of controls did not, and suggested that systemic inflammation in APLAID is driven by increased activation of the NLRP3 inflammasome (20).