However, human CD4 T cell clones from a patient with primary APS (40) responded to this peptide in the context of a single HLA-DR allele, DRB1*04:03, an allele that has been associated with the presence of aPL (both anti-CL and anti-β2GPI) in a European cohort of SLE patients (65). This evidence concerns the gene APOH and autoimmune polyendocrinopathy.