However, their findings showing increased β2GPI production in E. gallinarum-colonized liver and decreased anti-β2GPI autoantibody production in antibiotic-treated mice support a potential role for microbiota in the APS- and SLE-related manifestations observed in (NZW × BXSB)F1 hybrid mice. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.