Again, cells treated with either sRAGE or anti-FcRIIa antibody showed a significantly reduced induction of either IFIT1 or Mx1 following incubation with SLE sera, confirming that activation of either RAGE or FcRlla by SLE serum can contribute to the induction of ISGs in healthy monocytes (Figure 1D). This evidence concerns the gene IFIT1 and systemic lupus erythematosus.