Again, cells treated with either sRAGE or anti-FcRIIa antibody showed a significantly reduced induction of either IFIT1 or Mx1 following incubation with SLE sera, confirming that activation of either RAGE or FcRlla by SLE serum can contribute to the induction of ISGs in healthy monocytes (Figure 1D). The gene discussed is MX1; the disease is systemic lupus erythematosus.