Here, we report that tobacco smoke induces p97 promoter activation in CaSki (HPV16, 500 copies/cell) and SiHa (HPV16, 2 copies/cell) cervical cancer-derived cells and this activation involves EGFR activation and c-Jun phosphorylation which in turn, is recruited to TRE sites on the HPV16 LCR. This evidence concerns the gene JUN and cervical carcinoma.