To summarize we can hypothesize that, as shown in vivo (23, 24, 56), the antitumor effect of lenvatinib, and vandetanib in the tumoral cells could be linked to the following combination: (1) the antiproliferative action associated with the rise in apoptosis; (2) the inhibition of ERK1/2 phosphorylation (20); (3) the inhibition of tumor neovascularization (18, 56). This evidence concerns the gene MAPK3 and neoplasm.