Elevated levels of ADAR2 lead to editing and reduction of solute carrier family 22 member 3 (SLC22A3; N72D), which in turn promotes metastasis in familial ESCC by inhibiting the interaction between SLC22A3 and its inhibitory target α-actinin-4 (ACTN4), an actin-binding protein facilitating filopodia formation (57). Here, ADARB1 is linked to esophageal squamous cell carcinoma.