Curiously, this seemingly straightforward assertion of “ADAR2 edits COPA to suppress tumorigenesis” is complicated by recent studies showing that (i) ADAR2 is overexpressed in a small subset of HCC (55); and (ii) edited COPA has been shown to promote a malignant phenotype of BC cells in vitro (15). The gene discussed is ADARB1; the disease is hepatocellular carcinoma.