In metastatic melanoma, RNA editing-incompetent ADAR1 is able to negatively regulate the expression of the metastatic enhancer integrin beta-3 (ITGB3) by (i) inhibiting the transcriptional activator of ITGB3, PAX6, and (ii) promoting FOXD1-mediated induction of miR22 to block ITGB3 translation (147). Here, ITGB3 is linked to metastatic melanoma.