INS and Insulin resistance: Doxorubicin treatment caused a significant ↓ epididymal adipose tissue weight and adiponectin an increase in serum insulin, glucose, FFA concentration levels compared to saline controls. Doxorubicin treatment caused a decreased HOMA-IR (measurement of insulin resistance) and glucose uptake vs. control animals, which is indicative of impaired insulin sensitivity, and these animals displayed insulin resistance, hyperglycaemia, and hyperinsulinemia.