Doxorubicin treatment caused a significant ↓ epididymal adipose tissue weight and adiponectin an increase in serum insulin, glucose, FFA concentration levels compared to saline controls. Doxorubicin treatment caused a decreased HOMA-IR (measurement of insulin resistance) and glucose uptake vs. control animals, which is indicative of impaired insulin sensitivity, and these animals displayed insulin resistance, hyperglycaemia, and hyperinsulinemia. This evidence concerns the gene INS and hyperinsulinism.