During the progression of ICH, the acute response of ICH event does not activate the hemostatic systems unless intraventricular hemorrhage or intracerebral bleeding expands into the ventricles, causing arterial blood in contact with cerebrospinal fluid directly, which results in the generation of thrombin-antithrombin complex and plasmin-antiplasmin complex, as well as d-dimer accumulation (5). Here, PLG is linked to Intraventricular hemorrhage.