SYNE1 and aceruloplasminemia: Mutations in SYNE1 were first discovered to cause autosomal recessive cerebellar ataxia among French-Canadian pedigrees in 2007, referred to as autosomal recessive cerebellar ataxia type 1 (ARCA1), also called spinocerebellar ataxia autosomal recessive 8 (SCAR8), which is described as an adult-onset, relatively pure cerebellar ataxia (1).