Overall, from the assessed antidepressant drugs for ICH-induced depression, we found that several drugs exerted their antidepressant-like effects via different signaling pathways and may have different pathophysiological origins (e.g., ketamine could treat depression through mTOR signaling cascade, the MAPK/P38 pathway or TLR-related signal pathways). The gene discussed is MAPK14; the disease is depressive disorder.