The placenta in hypoxic conditions releases different substances into the maternal circulation, these include anti-angiogenic soluble fms-like tyrosine kinase 1 (sFlt-1) factors, and pro-inflammatory factors like tumor necrosis factor alpha (TNF-α) (Reyes et al., 2012), which are associated to maternal endothelial dysfunction (Roberts K.A. et al., 2011). The gene discussed is TNF; the disease is endothelial dysfunction.