We have determinated the levels of cytokines that are produced in the adipose tissue in patients with diseases as metabolic syndrome and type 2 diabetes mellitus, showing that plasma adiponectin levels are decreased, while proinflammatory cytokines as TNF-α and interleukin-6 (IL-6) are elevated, developing a proinflammatory state characterized by insulin resistance and endothelial dysfunction (Teran et al., 2001; Gómez-Arbeláez et al., 2013; Lopez-Jaramillo et al., 2014; Lopez-Jaramillo, 2016). The gene discussed is ADIPOQ; the disease is endothelial dysfunction.