Leptin administration to non-obese subjects suffering from sepsis syndrome and endotoxemia improves survival, probably by mediating the activity of the immune response (Madiehe et al., 2003; Dong et al., 2013; Landgraf et al., 2014; Siegl et al., 2014; Negrin et al., 2017). This evidence concerns the gene LEP and serum lipopolysaccharide activity.