Mutations in SCN5A may also lead to overlapping phenotypes (SCN5A overlap syndromes), where clinical characteristics of LQTS, BrS, and other arrhythmia syndromes, e.g., conduction disease and sinus node dysfunction, coexist in a single family or even in a single patient (Remme et al., 2008; Giudicessi et al., 2018). This evidence concerns the gene SCN5A and connective tissue disorder.