AGT and chronic kidney disease: Normobaric hypoxia may be induced by a variety of conditions that reduce the supply of oxygen to organs, such as chronic obstructive pulmonary disease (Kent et al., 2011), obstructive sleep apnea syndrome (Chiang, 2006), CKD (Shoji et al., 2014), and certain conditions that induce local renal hypoxia like cyclosporine A, hypokalemia, angiotensin II or contrast media (Lombardi et al., 2001; Suga et al., 2001; Zhou and Duan, 2014; Fähling et al., 2017).