Zhang et al. (2018) have elegantly shown that chylomicron uptake by the lacteals is regulated by dynamic changes of cell-cell junctions via VEGF-A signaling through VEGFR-2. Zippering of lacteal junctions prevents chylomicron uptake and protects mice from diet-induced obesity (Zhang et al., 2018). The gene discussed is KDR; the disease is obesity due to melanocortin 4 receptor deficiency.