Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA) was also listed among the top pathways (Table 8), which was consistent with a recent study showing that HADHA is involved in the development of type II diabetes via TGF-β regulation (Bohm et al., 2016). The gene discussed is TGFB1; the disease is type 2 diabetes mellitus.