Very recently, in a DKD murine model, Brennan has also identified a series of transcripts regulated by LXA4 and Benzo-LXA4, modulating well established (TGF-β1, PDGF, TNF-α, NF-κβ) and novel (early growth response-1) networks in DKD, demonstrating that LXs can reverse established diabetic complications and supporting a therapeutic paradigm to promote the resolution of inflammation (Brennan et al., 2018b). This evidence concerns the gene TNF and diabetic kidney disease.