GRK5 and hypertensive disorder: At the specific disease level, the expressional regulation and activity of GRK5 has been linked with multiple age-related diseases such as type 2 diabetes mellitus (T2DM) (Li et al., 2013), cardiac hypertrophy (Gold et al., 2012), hypertension (Harris et al., 2008), Parkinson’s disease (Arawaka et al., 2006; Bychkov et al., 2008), and Alzheimer’s pathology in mice and humans (Suo et al., 2007).