This classical function of GRK5 results in the promotion of the oligomerization of PD (with actual co-localization of GRK5 and SNCA), facilitating the creation of pathological Lewy bodies in the substantia nigra and locus coeruleus of PD patients (Pronin et al., 2000; Arawaka et al., 2006; Bychkov et al., 2008). The gene discussed is GRK5; the disease is Parkinson disease.