MAPT and Alzheimer disease: As a prelude to our next section, it is intriguing to note that GRK5 can be further connected with AD through its ability to phosphorylate α-synuclein (SNCA) (Pronin et al., 2000; Arawaka et al., 2006; Bychkov et al., 2008), tubulin as well as the AD-associated tau protein (Zhang et al., 2014).