Based on our present study, the in vitro experiments further confirm that the baicalein from SBD combat NSCLC via regulating the critical proteins of our integrated NSCLC-pathway including COX-2, NF-κB, Bax, ERK, CDK1 and so on, attesting that NSCLC can be treated through a complex system with multi- compound-target-disease interactions. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.