Gating mutants such as G551D (and others) respond very well to the CFTR potentiator, Ivacaftor, as well as a number of residual function mutations (De Boeck and Amaral, 2016) and next generation correctors appear able to restore some function to the most common CF-causing mutation (F508del) (Taylor-Cousar et al., 2017; Vertex, 2017). The gene discussed is CFTR; the disease is cystic fibrosis.