Administrate resveratrol (200 mg/kg bodyweight) to rats under high fat diet conditions significantly prevented hepatic steatosis and hepatocyte ballooning after 18-week treatment, along with the up-regulation of SIRT1 and autophagy markers LC3-II, Beclin 1, and P62 (Ding et al., 2017). The gene discussed is SIRT1; the disease is Hepatic steatosis.