In the present study, pretreatment with KOK significantly activated Nrf2 signaling associated with inhibition of MAPKs and NF-κB signaling, mitigation of neurological disorders, and reduction of dopaminergic neurodegeneration and inflammation in the SNpc and striatum after MPTP intoxication (Figures 1–5). This evidence concerns the gene NFKB1 and nervous system disorder.