In the present study, pretreatment with KOK significantly activated Nrf2 signaling associated with inhibition of MAPKs and NF-κB signaling, mitigation of neurological disorders, and reduction of dopaminergic neurodegeneration and inflammation in the SNpc and striatum after MPTP intoxication (Figures 1–5). The gene discussed is NFE2L2; the disease is nervous system disorder.