TNF and rheumatoid arthritis: During the inflammatory reaction, macrophages become secreted and activate due to release of an excessive amount of inflammatory mediators viz., IL-1β, TNF-α, and IL-6; that have been linked to the numerous inflammatory disease including rheumatoid arthritis, Crohn’s disease, cancer, asthma, Alzheimer’s disease, auto-immune pathologies, and psoriasis to name few (Kmieć, 2001).