Of this 8-protein panel, three proteins, CC4, TTR, and IGFBP-2, overlapped with previous studies (Bennett et al., 2012; Uchida et al., 2015; McLimans et al., 2017) and affect immunology, Aβ fibril formation, DNA synthesis, and cell proliferation and death in AD. This evidence concerns the gene IGFBP2 and Alzheimer disease.