Although only two proteins were found to be significantly different between AD and controls, they identified that a 10-protein panel (TTR, CLU, cystatin C, A1AcidG, ICAM-1, CC4, pigment epithelium-derived factor, A1AT, RANTES, and ApoC3) could predict the progression of MCI to AD with high diagnostic accuracy. The gene discussed is CLU; the disease is Alzheimer disease.