APOA1 and Alzheimer disease: Decreased ApoA-1 levels in AD versus controls (Liu et al., 2006; Shih et al., 2014) and in association with increased risk of clinical progression to MCI and AD (Slot et al., 2017) and PiB PET amyloid (Ashton et al., 2015; Westwood et al., 2016) have also been shown.