MAPT and early-onset autosomal dominant Alzheimer disease: The accumulation of amyloid-beta (Aβ) plaques followed by the deposition of hyper-phosphorylated tau protein in neurofibrillary tangles, central to Alzheimer’s disease (AD) neuropathology, is thought to develop around 20 to 30 years in advance of clinical symptom onset (Jansen et al., 2015).