We have utilized a proteomic approach to analyze blood samples from our in-house repetitive mTBI model in wild-type mice (Mouzon et al., 2012; Ojo et al., 2013; Mouzon et al., 2014, 2018a,b; Ojo et al., 2015), and the PSAPP [(PS1(M146L), APP(K670N, M671L)] and hTau [expressing all six isoforms of human tau, and lacking expression of murine tau] mouse models of AD that develop primarily amyloid and tau-based pathologies, respectively (Holcomb et al., 1998; Andorfer et al., 2003). Here, APP is linked to Alzheimer disease.