MAPT and Alzheimer disease: Indeed, in this same cohort we have conducted proteomics analyses of brain tissue at the same time points of analyses described in this current work, and we present distinct and overlapping proteomic response to injury in our TBI model compared with AD mouse models, indicating a distinct TBI mediated neurodegeneration (not related to tau or amyloid pathology), that also shares features with AD pathogenesis (Ojo et al., pers comm).