PRKN-associated PD is characterized by pure degeneration in the SNc and locus coeruleus without LB pathology and occasional Tau inclusions (Schneider and Alcalay, 2017), whereas PINK1 mutations lead to nigral neurodegeneration with LB and neurites (Samaranch et al., 2010), and DJ1-associated pathology includes severe degeneration in the SNc and locus coeruleus with diffuse LBs and axonal spheroids (Taipa et al., 2016). Here, PRKN is linked to Parkinson disease.