MAPT and Parkinson disease: The variants in MAPT (Pastor et al., 2000; Golbe et al., 2001; Caffrey and Wade-Martins, 2007) and SNCA (Botta-Orfila et al., 2011; Cardo et al., 2012; Brockmann et al., 2013) loci showed the strongest association with PD risk across populations and most importantly, also at the GWAS level (Simón-Sánchez et al., 2009; Bonifati, 2010; Nalls et al., 2014) correlating not only with higher risk but with increased disease age-at-onset as well (Wang G. et al., 2016).