Moreover, mutations in HtrA Serine Peptidase 2 (HTRA2) (Strauss et al., 2005) and vesicle protein sorting 35 (VPS35) (Vilariño-Güell et al., 2011; Zimprich et al., 2011) are responsible of typical L-DOPA responsive PD, although no neuropathological data is not available yet. Here, VPS35 is linked to Parkinson disease.