In this context, it would be intriguing to investigate whether treatment with exogenous TRH or taltirelin, which is a synthetic TRH analog, could restore cerebellar LTD in mouse models of SCA demonstrated to exhibit defects in cerebellar LTD (Shuvaev et al., 2011, 2017). The gene discussed is TRH; the disease is autosomal dominant cerebellar ataxia.