NGF and Alzheimer disease: Reduction of ChAT- labeled nerve endings, deficiency in cholinergic transmission and spatial learning/memory ability along with downregulation in expression of NGF and its cognate receptors have been detected in aging Tg2576 animals (Apelt et al., 2002; Chauhan and Siegel, 2003; Klingner et al., 2003; Lüth et al., 2003; Simmons et al., 2014; Zhu et al., 2017, a transgenic AD mouse line carrying the mutated form of APP named AβPPSWE (K670N/M671L).