Rat models of hypothyroidism exhibited increases of APP protein (Contreras-Jurado and Pascual, 2012), tau hyperphosphorylation, proinflammatory cytokines and spatial memory impairments (Chaalal et al., 2014), indicating that hypothyroidism represents an important risk factor of developing sporadic forms of AD. The gene discussed is MAPT; the disease is hypothyroidism.