MPTP and rotenone caused an elevation of p-tau (S396), p-α-synuclein (S129), tau N368 and α-synuclein N103 fragments in SH-SY5Y cells and in the SN of PD mouse models, while Taltirelin successfully reduced the levels and aggregation of tau or α-synuclein in toxic forms. This evidence concerns the gene MAPT and Parkinson disease.