TRH and Alzheimer disease: TRH has long ago been proved useful in multiple animal models of diseases such as brain/spinal cord injuries (Faden et al., 1981; Pitts et al., 1995), depression (Szuba et al., 1995; Marangell et al., 1997), epilepsy (Jaworska-Feil et al., 2001; Kubek et al., 2009), schizophrenia (Wilson et al., 1973), amyotrophic lateral sclerosis (ALS; Hawley et al., 1987; Brooks, 1989), Alzheimer’s disease (AD; Mellow et al., 1989; Molchan et al., 1990) and Parkinson’s disease (PD; Ogata et al., 1998).