MAPT and Parkinson disease: In this study, we showed that Taltirelin significantly reduced the toxicity of MPP+ and rotenone in SH-SY5Y cells and rat primary SN neurons, ameliorated the behavioral disturbance induced by MPTP or rotenone in PD mice via inhibiting MAO-B activity and reactive oxygen species (ROS) generation, reducing the abnormal phosphorylation of α-synuclein and tau, inhibiting the activation of AEP and its specific cleavage effect, thus provides evidence for Taltirelin in protective treatment of PD.