PPARγ, the most studied PPAR isoform, has shown the most potent neuroprotective effects in different models of neurodegenerative disorders such as I/R-induced brain injury and AD (Zhao et al., 2006; Zolezzi et al., 2014; Wu et al., 2016; Chen et al., 2018). The gene discussed is PPARA; the disease is Alzheimer disease.