Besides aging, new genetic risk factors for AD were reported recently in GWAS, such as ApoJ/Clusterin, PICALM, complement receptor 1 (CR1), TREM2 and sialic-binding immunoglobulin (Ig)-like lectin CD33 (Lambert et al., 2009; Naj et al., 2011; Hollingworth et al., 2012; Guerreiro et al., 2013; Jonsson et al., 2013). The gene discussed is CLU; the disease is Alzheimer disease.