An increased intracellular Ca2+ concentration due to increased NMDAR activity and/or other Ca2+ sources, including the InsP3R1 (inositol 1,4,5-trisphosphate receptor type 1) and store-operated Ca2+ entry, was also suggested to underlie the striatal neurodegeneration in HD (Tang et al., 2003, 2004; Wu et al., 2016). Here, ITPR1 is linked to Huntington disease.