ADORA2A and attention deficit-hyperactivity disorder: Our findings reveal that the downregulation of A2AR in the PLmPFC decreased the choice of the large reward in a T-maze-based cost-benefit paradigm in which the cost was delay, suggesting an increase in impulsive decision making, a finding relevant for disorders with impaired decision making, such as Parkinson’s disease, schizophrenia, ADHD and addiction (Lee, 2013).