Although previous human genetic association studies implicate polymorphisms of the A2AR gene in caffeine-induced anxiety (Alsene et al., 2003; Tsai et al., 2006), there is some discrepancy on the impact on anxiety-like behaviors of A2AR genetic deletions and A2AR pharmacological antagonism (e.g., Ledent et al., 1997; El Yacoubi et al., 2000; Kaster et al., 2015) as well as A2AR overexpression (Giménez-Llort et al., 2007; Coelho et al., 2014). Here, ADORA2A is linked to Anxiety.