Thus, we anticipated a role for PFC A2AR in the control of PFC-dependent behaviors, which include anxiety-like behavior (Calhoon and Tye, 2015; Tovote et al., 2015), cost-benefit decision-making (Bailey et al., 2016) and working memory (Goldman-Rakic, 1999; Fuster, 2001). The gene discussed is ADORA2A; the disease is Anxiety.