Several animal models of ALS based on mutations of TDP-43 have been generated, from mouse models to yeast, including zebrafish (Patten et al., 2014; Van Damme et al., 2017), but how ALS-causing mutations of TDP-43 induce the pathophysiological changes seen in ALS patients is still poorly understood. Here, TARDBP is linked to amyotrophic lateral sclerosis.