TARDBP and amyotrophic lateral sclerosis: These results recapitulate the phenotype obtained by overexpression of mutant TDP-43 mRNA by our group and others (Kabashi et al., 2008, 2010; Laird et al., 2010; Vaccaro et al., 2012, 2013; Armstrong and Drapeau, 2013; Patten et al., 2017), thus validating our transgenic lines as genetic models of TDP-43-related ALS that can be used to better understand the pathophysiology of TDP-43 pathogenicity in ALS.