CACNA1C and schizophrenia: Of the other loci that reached genome-wide significance within either the schizophrenia data set or within a joint data set including bipolar disorder patients, four loci were associated with validated mRNA targets of miR-137: TCF4, CACNA1C, CSMD1, and C10orf26 (Kwon et al., 2011; Ripke et al., 2011).