Nrg1α-induced PI3K signaling is also impaired in lymphoblastoid cell lines derived from schizophrenia patients (Law et al., 2012), suggesting PI3K-Akt-mTOR signaling in response to Nrg1 may be impaired in schizophrenia in a manner that mirrors the effects of reduced miR-137. This evidence concerns the gene AKT1 and schizophrenia.