Although we do not have cognitive data in our cohort to assess the relationship of ApoE status to cognitive function, prior studies have shown that E2 carriers show less severe cognitive deficits compared to E3 and E4 carriers (Serrano-Pozo et al., 2015), even when levels of pathological forms of tau and Aβ are similar (Berlau et al., 2009), suggesting that the protective effects of the E2 allele may be independent from its effects on Aβ and tau pathology. The gene discussed is APOE; the disease is Cognitive impairment.