We also assessed whether each module was significantly correlated with ApoE status and ApoE-associated AD risk using an ordinal scale in which an E3 allele was equal to 0, E2 was equal to −1, and E4 was equal to 1 (therefore, an E4/E4 carrier would equal 2, while an E2/E3 carrier would equal −1). The gene discussed is APOE; the disease is Alzheimer disease.