In line with miR-22 targeting P2X7 during epilepsy (Engel et al., 2017), P2X7 protein levels in the contralateral hippocampus are higher in Ant22-treated epileptic mice when compared to epileptic Scr-treated mice, even 6 weeks following SE with this increase most evident in the subgranular zone of the DG (Figure 1I). This evidence concerns the gene P2RX7 and epilepsy.