Single-nucleotide polymorphisms (SNPs) in the α1 subunit (CACNA1C) of the L-type calcium channels Cav1.2 rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression (Casamassima et al., 2010; Dedic et al., 2018) and more recently with treatment resistant depression (Fabbri et al., 2018). The gene discussed is CACNA1C; the disease is depressive disorder.