Since overexpression of the Teneurin-1-ICD increased resistance to this drug in glioblastoma (Talamillo et al., 2017), interaction of Teneurin-1 and MACF1 might contribute to this phenotype, possibly involving the stabilization of actin and microtubule cytoskeletal structures and WNT signaling activity. The gene discussed is MACF1; the disease is glioblastoma.