In line with this notion, a recent study using CRISPR-CAS9 to knock-out ZEB1, a homeobox transcription factor that mediates epithelial to mesenchymal transition (EMT) in response to TGF-ß, found that Teneurin-2 transcription is directly repressed by ZEB1 in triple-negative breast cancer cells (Maturi et al., 2018). This evidence concerns the gene TENM2 and triple-negative breast carcinoma.