Since basal expression of KSR1 (Kinase Suppressor of Ras 1) was reported in HL60 acute promyelocytic leukemia cells (Wang et al., 2006), a transcriptionally active KSR1 promoter might be expected in leukemia and drive de novo expression of TENM1, with potential functional consequences. The gene discussed is KSR1; the disease is acute promyelocytic leukemia.