Hence, focal adhesion kinase (FAK)-dependent signaling was induced by Teneurin-4 in neuroblastoma cells, and phosphorylated FAK colocalized with Teneurin-4 at sites of neurite protrusion formation, together with the Rho GTPases cdc2 and Rac1 (Suzuki et al., 2014b). This evidence concerns the gene TENM4 and neuroblastoma.