Moreover, altered expression of CRMP2 has been previously demonstrated in Alzheimer’s disease, Parkinson’s disease, alcohol-induced neurodegeneration, and traumatic brain injury (Barzilai et al., 2000; Kobeissy et al., 2006; Matsuda-Matsumoto et al., 2007). This evidence concerns the gene DPYSL2 and early-onset autosomal dominant Alzheimer disease.