To elucidate the underlying mechanism by which PTSD induces tau accumulation, Miller et al. investigated the influence of the lipoxygenase genes ALOX12 and ALOX15 (enzymes involved in inflammatory responses) on the decreasing cerebrocortical thickness seen in subjects with PTSD, and found that ALOX12 moderates the association between PTSD severity and thinning of the prefrontal cortex [49]. This evidence concerns the gene ALOX15 and post-traumatic stress disorder.